Fecal microbiota transplantation via nasogastric tube for recurrent clostridium difficile infection in pediatric patients.
نویسندگان
چکیده
Fecal microbiota transplantation (FMT) is a safe and effective therapy for adults with recurrent Clostridium difficile colitis, but data regarding FMT in children are limited and focus on colonoscopic administration of FMT. We present 10 consecutive children who received FMT via nasogastric tube for treatment of recurrent C difficile infection. Median age was 5.4 years, and 30% were receiving simultaneous immunosuppression. Median follow-up was 44 days, and 90% of patients resolved their C difficile infection; one patient relapsed 2 months later after receiving antibiotics. FMT via nasogastric tube appears safe, well tolerated, and effective in treating pediatric recurrent C difficile colitis.
منابع مشابه
Fecal microbiota transplantation for the treatment of Clostridium difficile infection: a systematic review.
GOAL By systematic review, we assessed the impact of fecal microbiota transplantation (FMT) for the treatment of Clostridium difficile (CD)-associated diarrhea. BACKGROUND Fecal microbiota microbiota transplantation from a healthy donor into an individual with CD infection (CDI) can resolve symptoms. STUDY We conducted systematic searches in PubMed, SCOPUS, Web of Science, and Cochrane Libr...
متن کاملRecurrent Clostridium difficile infection treated with home fecal transplantation: a case report
INTRODUCTION Clostridium difficile infection causes severe diarrhea, abdominal pain and weight loss. A course of metronidazole is the initial treatment; however up to 40% of patients have at least one recurrence. Some patients have recurrent infections requiring further treatment with vancomycin, others need multiple courses of expensive treatment. Fecal transplantation has been proposed as an ...
متن کاملFecal microbiota transplantation in patients with cancer undergoing treatment.
Fecal microbiota transplantation (FMT) is a technique used to restore the normal body flora to the gut in cases of Clostridium difficile infection (CDI). It involves instillation of the stool of a healthy donor through a nasogastric tube or colonoscopy into the gastrointestinal tract of the patient. More research is needed to determine the parameters of FMT use in patients with cancer.
متن کاملPerceptions of fecal microbiota transplantation for Clostridium difficile infection: factors that predict acceptance
BACKGROUND Despite the effectiveness of fecal microbiota transplantation (FMT) for treating recurrent Clostridium difficile (C. difficile) infection, some patients are reluctant to accept this therapy. Our study examined attitudes towards FMT and factors that contribute to patients' acceptance of this treatment. METHODS We distributed patient surveys at a Veterans Affairs hospital, a public h...
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ورودعنوان ژورنال:
- Journal of pediatric gastroenterology and nutrition
دوره 60 1 شماره
صفحات -
تاریخ انتشار 2015